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Despite its widespread clinical utility, oral N-Acetyl-L-Cysteine is characterized by remarkably poor bioavailability

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It functions as an electron carrier in cellular respiration and as a substrate for sirtuins (longevity proteins) and PARP enzymes (DNA repair proteins)

Each of these multiple reactions require a specific enzyme, thus conversion is a complex process, even for a healthy person

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Philbert MA, Beiswanger CM, Waters DK, Reuhl KR, Lowndes HE