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10.12998/wjcc.v10.i22.7653 76 OlivaS.Di NardoG.FerrariF.MallardoS.RossiP.PatriziG.et al (2012)

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The reduction in BW from baseline was 22% at the maximum dose tested (mean SEM, 100 nmol/kg from 43.6 1.6 g to 34.8 1.4 g) and 10% from baseline at the lowest dose tested (mean SEM, 1 nmol/kg, from 42.5 1.3 g to 38.2 1.3 g) (Figure 1, A and B)

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Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism