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That bleeding advantage disappears when strong dual inhibitors of CYP3A4 and P-gp (ketoconazole, ritonavir, clarithromycin) are co-administered, as apixaban exposure can increase by up to 100% [1]
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Preserve cellular integrity and function
185 In normal cells, DDR is indispensable for maintaining genomic fidelity and preventing malignant transformation
The standard Health Canada review timeline for generic drug applications is 180 days, though complex submissions may require additional time for assessment
third-party testing is recommended for critical applications
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