When adverse effects do occur, they are usually mild and transient, often related to the route of administration rather than the vitamin itself
Jafari F, Arasteh O, Hosseinjani H, Allahyari A, Ataei Azimi S, Askari VR (2023) A critical review of methotrexate clinical interactions: role of transporters
A., Collins, J
ORiordan KJ, Moloney GM, Keane L, Clarke G, Cryan JF (2025) The gut microbiota-immune-brain axis: therapeutic implications
While published research generally reports favorable tolerability, comprehensive long-term human safety studies have not yet been completed
(Source 4) Bottom line: If you take glutathione supplements to boost levels, drinking alcohol will be counterproductive