Liraglutide is sold as Saxenda and works through the same GLP-1 receptor agonist mechanism as semaglutide and tirzepatide, mimicking GLP-1 to regulate appetite and blood sugar rather than acting on the GIP pathway that tirzepatide also targets
PLoS One 2016, 11: e0148827
78,79 A retrospective study conducted in Turkey reported that treatment with EX-BID led to significant decreases in NFS and APRI scores, although FIB-4 showed a completely opposite trend
This represents an exposure of about 2- and 6-times a 2000 mg clinical dose based on body surface area (mg/m2) for rats and rabbits, respectively
During this time, the group advanced several peptide clinical candidates, including tirzepatide, currently approved for diabetes management and weight control
But people who took the drugs in these studies did report pancreatitis