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Retinal pigment epithelial cell-secreted IGF-1 may be a source for IGF-1R activation in the retina

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CDK1 directly binds and phosphorylates the S447 site of ACSL4, promoting the ubiquitination degradation of ACSL4, while genetic and pharmacological blocking of CDK1 enhances ACSL4 activity, promoting ferroptosis of colon cancer cells and increasing their susceptibility to oxaliplatin

PMID: 40908429 | doi:10.1007/s10522-025-10315-x

What are the risks of sourcing a GLP-1 outside the healthcare system