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A post hoc analysis in Japan indicated that the combination of SGLT2i and GLP-1RA was superior to monotherapy in improving liver function parameters (ALT, AST), hepatic steatosis index (HSI), and fibrosis index (FIB-4), suggesting complementary mechanisms between the two
GIP enhances insulin sensitivity while also contributing to appetite regulation
7 , e12139 (2021)
Last Updated On 24 Jul
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One concern is the lack of conclusive evidence for GLP-1R expression in the liver
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