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5, May 2006, pp

however, a significant increase in the GR activity was observed from day 15 onward

However, full effect may not develop for four to eight weeks as the medication reaches steady-state concentration and the brains appetite circuits fully adapt

doi: 10.1186/s12891-015-0516-3 70 LeeAQiaoYGrigorievGChenJPark-MinKHParkSHet al