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In a mouse model of stroke, intracerebroventricular sodium selenate treatment elevates GPX4 levels by activating transcription factors activating enhancer binding protein 2 and specificity protein 1, while also providing protection against excitotoxicity and endoplasmic reticulum stress-induced cell death independent of GPX4 (102)

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Micromachines 14(5):1017 Trenz TS, Delaix CL, Turchetto-Zolet AC, Zamocky M, Lazzarotto F, Margis-Pinheiro M (2021) going forward and back: the complex evolutionary history of the gpx

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In addition, there was a pre-specified stopping rule, with a recruitment pause and ad-hoc review by the TSC and DSMC mandated should two out of any six consecutive recipients experience early graft loss

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