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Tesamorelin acetate administration to rats during organogenesis and lactation resulted in hydrocephalus in offspring at a dose approximately two and four times the clinical dose, respectively, based on measured drug exposure (AUC)

This activation subsequently triggers downstream effector caspases, such as Caspase-3, leading to a cascade reaction of apoptosis and ultimately resulting in cell death

Animal studies typically show improvements in tissue repair within days to a few weeks

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The ordinary type is 24 months