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Additionally, elevated serum lactate is also an important marker for intracerebral hemorrhage (ICH) [96]
Other candidates, such as compound 3 from the NCI-3D database 200 , DIMN analogs termed 7AU and 7BB 201 , and MEL-3 202 , all showed encouraging in vitro activities and need to be tested in animal models
Safety Data Limits : According to an FDA briefing, animal studies revealed possible liver or bone-related risks at high doses, and current human data are limited
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