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Pemvidutide Pemvidutide, another weekly GLP-1/glucagon dual agonist, is under evaluation in the ongoing phase 2 IMPACT trial (NCT05989711) in 190 individuals with histologically confirmed MASH and fibrosis stages F2-F3 [47]
Shibayama, K
The clinical development program was discontinued due to insufficient weight loss efficacy rather than safety concerns
It is now clear that GPR39 is not the receptor for obestatin and the original observation was likely the result of zinc in the preparations of obestatin
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