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GHK-Cu is highly sensitive to carboxypeptidase cleavage, light-driven copper photo-oxidation and pH extremes, with an optimal range of about 5.0 to 6.5
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The peptide has demonstrated efficacy in normalizing pathological blood pressure states, reversing hypertension induced by NOS inhibitors and attenuating hypotension induced by excessive NO substrate administration, indicating adaptive vascular regulation
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10.1016/j.freeradbiomed.2007.11.008 Free Radic Biol Med
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