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Until further evidence is published, we limit performing laser treatment of CMN

Phentermine, a primary aliphatic amine, cannot undergo deamination as the -carbon does not contain hydrogen and the drug is therefore N-hydroxylated

The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )

The more severe health risks include: An increased risk of death from cardiovascular disease

Once-Weekly Efpeglenatide Dose-Range Effects on Glycemic Control and Body Weight in Patients With Type 2 Diabetes on Metformin or Drug Naive, Referenced to Liraglutide

& Isaacs, J