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Semaglutide and tirzepatide mimic a class of hormones called incretins, which help regulate appetite, blood sugar, and digestion
Ozempic and Wegovy are weekly injections while Rybelsus is an oral medication taken daily
All participants gave full informed written consent and underwent an MRS scan and a computerised cognitive assessment
A history of pancreatitis, certain thyroid cancer concerns, pregnancy, or other contraindications requires careful review by the prescribing clinician
Akil H, Burgess J, Nevitt S, Harding SP, Alam U, Burgess P
Participants were treated with: Ixekizumab (an IL-17 inhibitor) alone Ixekizumab plus tirzepatide (a dual GLP-1/GIP receptor agonist) The rationale for combination therapy reflects emerging evidence that obesity contributes to systemic inflammation and may attenuate response to biologic therapy in PsA
