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Supplementing with riboflavin altered the DNA methylation in people with MTHFR C677T, causing a decrease in methylation of the ACE gene.[ref] Benefits of supplemental riboflavin: Clinical trial data Clinical trials are an excellent way to know if a supplement is effective for most people

The researchers didnt find such an association in women, and it was mostly seen among men who smoked

Whether a person feels more energy is not something the trials measured

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The right dose within this range varies based on symptom severity and health conditions