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It is the fifth leading cause of deaths globally with 2.8 million adults dying each year with complications of obesity

Abstract Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death and mitochondrial dysfunction, particularly ferroptosis and mitochondrial injury

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Translation: the animal data is extremely strong, but the human data is basically anecdotal plus a couple of pilot studies