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Westermark P, Andersson A, Westermark GT
We next identify and map sites of cholesterol high occupancy and residence time on active versus inactive GLP-1Rs using coarse-grained molecular dynamics (cgMD) simulations, followed by a screen of key residues selected from these sites and detailed analyses of the effects of mutating one of these residues, Val229, to alanine on GLP-1R interactions with cholesterol, plasma membrane behaviours, clustering, trafficking and signalling in pancreatic beta cells and primary islets, unveiling an improved insulin secretion profile for the V229A mutant receptor
Vin ung Glutathione OneDay Collagen cha hm lng glutathione tinh khit kt hp vi collagen, gip tc ng trc tip vo c ch sc t c ch melanin
2026 Jan 21:S0168-8278(26)00016-4
