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The SELECT cardiovascular trial [2] confirmed these microbiome changes persist long-term, with sustained alterations in bile acid metabolism affecting gut bacterial composition even after 2 years of treatment at the 2 Easing constipation: Constipation is one of the most common semaglutide side effects

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Nausea from MT-1 results from off-target MC4R activation in the hypothalamus, which regulates appetite and emesis pathways