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doi:10.1097/GME.0000000000002310 Centers for Disease Control
A meta-analysis published in 2023 included individual participant-level data from three randomized controlled trials that evaluated the effect of at least two years of vitamin D supplementation on risk of new-onset diabetes among people with prediabetes (Pittas 2023)
The Core Benefits of Microdosing Liver and Cardiovascular Protection A 72-week trial found 40% of patients achieved resolution of fatty liver disease without worsening fibrosis. In animal models, GLP-1s suppress fat production in the liver and reduce inflammation. Tirzepatide at low doses showed particularly strong cardiovascular benefits, with meaningful improvements across multiple lipid markers linked to heart disease risk. Cholesterol storage forms increased far less with tirzepatide, and harmful lipids like ceramides showed minimal increase compared to placebo
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