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While BPC 157 is generally well-tolerated, there are some risks and considerations to keep in mind: Potential Side Effects: Some individuals may experience mild side effects, including nausea or changes in appetite

In addition, exendin-4 treatment repressed mitochondrial dysfunction, as shown by lower levels of the mitochondrial function-associated genes MCU and UCP3, as well as the mitochondrial fission genes DRP1 and FIS1

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The paper currently receiving a good deal of attention as of this writing (September, 2025), is a Harvard/Mount Sinai study published in 2025