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Melanin is the pigment responsible for dark spots, acne marks, and uneven tone

Anal Biochem 241:7581 Gardner JM, Aust SD (2009) Quantification of hydroxyl radical produced during phacoemulsification

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In another randomized controlled trial in overweight adults with evidence of pre-existing vascular dysfunction, 450 mg per day of a hesperidin supplement for six weeks resulted in lower blood pressure and a decrease in markers of vascular inflammation (Salden 2016)

European Review for Medical and Pharmacological Sciences, 23 (12), 5512-5521