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What the Data Actually Show | Evidence Level | Sermorelin Alone | GHK-Cu Alone | Sermorelin + GHK-Cu | |---|---|---|---| | Phase III RCT | Yes (pediatric GHD) | No | No | | Phase II RCT (adults) | Yes (Vittone 1997) | One skin-aging trial | No | | Animal studies | Multiple | Multiple | None identified | | In vitro mechanistic | Extensive | Extensive | None identified | | Case series / observational | Limited | Limited | Anecdotal only | The FDA-approved indication for sermorelin covers pediatric GH deficiency
PMC Mechanism)
Tan et al., 2018)
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26 Biochemical abnormalities commonly seen in patients with ASD include impaired methylation, sulphation capacities and low glutathione (GSH) redox capacity, all of which can potentially respond to B12 supplementation
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