These challenges led to widespread shortages across nearly the entire class of GLP-1 medications
After propensity-score matching, the two cohorts (25,820 in each cohort, mean age 58.0 years, 45.4% women, 14.8% Black, 61.2% White, 6.7% Hispanic) were balanced (Table 2)
(1993) Biological Effects and Metabolic Rates of Glucagon-like Peptide-1 7-36 Amide and Glucagon-like Peptide-1 7-37 in Healthy Subjects are Indistinguishable
TRIUMPH-1's 28.3% and TRIUMPH-4's 28.7% remain the highest results in the program both trials enrolled patients without diabetes, unlike TRIUMPH-2 (which specifically included diabetes) and TRIUMPH-3 (which specifically included cardiovascular disease)
It is also contraindicated for women who are pregnant or planning to become pregnant
Lustig RH, Christensen ML, Tosson HM, Velasquez-Mieyer PA, Arheart KL, Danish RK, Burghen GA: Racial dichotomy in the Body Mass Index (BMI) response to metformin pharmacotherapy for obesity/insulin resistance in children