joint pain with semaglutide Once-Weekly Reduces Knee Osteoarthritis Pain, Body Weight in Patients Obesity, Suggesting Potential to Lower NSAID Use Joint Pain from Wegovy: Causes,

Simply put, its a tiny protein fragment (a peptide made of three amino acids) bound to a copper ion

Small-scale human studies have produced mixed and inconsistent results

Acta Physiol Plant 38(9):110

Eli Lilly is studying retatrutide in several phase-3 clinical trials for obesity, type-2 diabetes, knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatosis liver disease

[1] [11] This reduces the likelihood of drug-drug interactions at the metabolic level

This is why its effects are so widespread, from improving skins appearance to supporting wound healing