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C15 binding to ChemerinR1 activates the IB kinase (IKK) complex that phosphorylates IB at specific N-terminal residues (Ser32/Ser36), triggering its polyubiquitination and subsequent proteasomal degradation

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Also, 4-HNE induces Daxx protein level and promotes the export of Daxx from the nucleus to the cytosol in Jurkat T lymphocyte cells

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Patients with RBD-PD exhibited significantly greater motor impairment (Hoehn-Yahr stage, mean: 2.7 vs

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