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Tirzepatide (brand names Mounjaro for type 2 diabetes, Zepbound for obesity and sleep apnea) is a dual agonist that activates both the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors simultaneously
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Four -ketoacid dehydrogenase complexes ( Figure 4 ), including: (i) the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for energy production via the citric acid cycle
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Subcutaneous, in the abdomen, at night
The subsequent development of other GIP/GLP-1 receptor co-agonists confirmed these initial discoveries and the superior action profile of this drug class in obese rodents [85,86,87]
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