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Additionally, loss of muscle mass during rapid weight loss can reduce the efficiency of muscle pumps that help return blood from the extremities to the heart, leading to blood stasis, particularly in the legs, which is a risk factor for deep vein thrombosis (DVT)

However, this still leaves two-thirds of the heart benefits of semaglutide unexplained

The large-scale STEP clinical trials (Semaglutide Treatment Effect in People with Obesity), published in the New England Journal of Medicine and JAMA, did not report increased cold sensitivity as a significant adverse effect

Instead, think of your Tirzepatide meal plan as a fueling strategy

If you are also thinking about everyday vitality, the Energy & Focus collection is a helpful place to explore

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