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Since this regimen restricts methionine in the absence of cystine, we restricted both methionine and cystine in our cell culture DMEM medium by combining methionine/cystine-free DMEM with 10% dialyzed FBS, which resulted in a restricted DMEM medium (MCR) containing 0.12 M methionine and undetectable levels of cystine

This heightened sensitivity may represent an early or mild form of the same process that produces full allodynia at higher intensities

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It is taken once weekly using either a prefilled injectable single-use pen, a four-dose weekly KwikPen, or a vial and syringe