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The FDA approved it in April 2026
Metformin is contraindicated in patients with an eGFR 4 years) is associated with vitamin B12 deficiency in 10-30% of patients, likely due to interference with calcium-dependent B12 absorption in the terminal ileum
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4 It is assumed that GLP-1 may be involved in the stimulation of glucose disposal in peripheral tissues independent of insulin actions
[24] [10] [25] Four trials were conducted in ED, the last being a Phase IIb published in 2008
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