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Although less likely, such a scenario is not unusual, and has been visualized in the prototypical 2 adrenergic receptor: both ligand-free and antagonist-bound 2 adrenergic receptors can form a complex with nucleotide-free Gs 22,23

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Although metformin is a pharmacological option for patients living with obesity and PCOS, it does not significantly reduce weight or modify fat distribution

For example, someone with a lot of lean muscle mass and heavy, dense bones can come up high in BMIand even be categorized as having obesitywhen in reality, they have low body fat and high lean mass, placing them into a healthy body composition category

This can slow metabolic rate and make long-term weight maintenance more difficult