Lexicomp lists 374 interaction entries for sildenafil as of 2025, including 12 classified as "X: Avoid Combination" (primarily nitrate-containing products) and 48 classified as "D: Consider Therapy Modification" (including alpha-blockers, riociguat, and strong CYP3A4 inhibitors) [1]
Freitas-Cortez, M
The new formulas include: Clarity: similar to the previous formula but with added ginseng, less choline, and no L-theanine Motivation: similar to the previous formula but with mandatory caffeine, no phenylalanine, and added salidrosides from rhodiola Stress Reset: strikingly similar to the previous Confidence formula but with no sage or magnolia bark and added vitamin D and salidrosides from rhodiola Neuroprotection: a new formula targeting brain health with ingredients like spermidine, PQQ, and bacopa extract
Individuals seeking to support naturally radiant, even-toned skin
A 0.05% BAC legal limit is most common and found in Western European countries
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al