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Typical protocols range from 250-500 mcg daily, often split into twice-daily doses for optimal tissue levels
Recent evidence from the STEP-HFpEF and STEP-HFpEF-DM trials provides the first robust data supporting the efficacy of GLP-1 RAs, specifically semaglutide, in improving the quality of life in obese patients with HFpEF
Dizziness may be more noticeable when standing up quickly, after missing meals or not drinking enough fluids
Also, adding a very low-calorie diet to the treatment with semaglutide produced more weight loss than semaglutide alone
The initial dose is typically low0.25 mg once weeklyto minimize gastrointestinal side effects while your body adjusts
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