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The proline downstream metabolite, 1-pyrroline-5-carboxylic acid (P5C, also known as hydroxyproline), has implications for tumor aggressiveness

Although the downregulation of Gpx3 by pefloxacin was not observed, Achilles tendons from rats treated with only dexamethasone or with both pefloxacin and dexamethasone showed significantly higher gene expression levels of Gpx3 than those from vehicle-treated or pefloxacin-treated rats (Figure 5D)

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