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Two different selenium-dependent iodothyronine deiodinases (DIOs type 1 and 2) can deiodinate T 4 , thus increasing circulating T 3 , while a third iodothyronine deiodinase (DIO type 3) can convert both T 3 and T 4 to inactive metabolites ( Figure 3 ) (10, 11)
The prognostic impact of the reactive hyperemia index (RHI) in HFpEF patients suggests that endothelial dysfunction may not be merely a passive finding, but rather that endothelial function plays an active and crucial pathophysiological role in HFpEF [23]
Appetite suppression can reinforce restriction, meal avoidance, and disconnection from internal cues
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