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Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind-study

However, the modest effect does not negate the potential value of these drugs, especially for conditions where few effective treatment options exist, for example, dementia, Al-Aly says in a release

The weight lowering and glucoregulatory actions of both the mono- and the combination therapies are limited by model, as the HFD rat model does not develop diabetes, but only modest insulin resistance due to obesity

Combining them creates a situation where some of these overlap, some cancel each other out, and some amplify each other

You want to know your real cost up front

~ AlphaMD Most people asking whether sermorelin is safe are already doing something right - they are asking questions before starting, not after