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What a Herx Reaction Means Now Now, the term Herxheimer reaction is used more broadly to denote any response that creates uncomfortable symptoms while being effective overall

Steen Petersen and M

1998 Apr;30(2):159-68

Wegovy is administered as a once-weekly subcutaneous injection, with a dose-escalation schedule over 16 weeks to minimise gastrointestinal side effects

Trahair LG, Horowitz M, Stevens JE, Feinle-Bisset C, Standfield S, Piscitelli D, et al

Silky Patel emphasizes that adherence to this dosing schedule is essential for safety and for optimizing the injections role within a broader weight management strategy