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1981, pp
10.1016/s0140-6736(64)90011-x 53 MooreB
Whether GLP-1 medications have direct effects on testosterone production independent of weight loss is an active area of investigation
Based on data from RCTs in T1D and those with patients with T2D, initiation of a GLP-1RA should be followed by a decrease of total insulin dose to reduce events of hypoglycemia (71)
A proportion of participants also discontinued GLP-1 RA therapy after 3 years and it is well described that individuals can re-gain two-thirds of their initial weight loss upon cessation of GLP-1 RA [44]
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