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This glucagon-like peptide-1 (GLP-1) receptor agonist encourages insulin secretion from the pancreas, slows gastric emptying, and reduces appetite, resulting in higher energy expenditure and lower food consumption

N Engl J Med (2016) 375(4):31122

"People living with obesity have long been denied access to the essential treatment and care needed to manage this serious chronic disease," said A four-week supply of the 2.5 mg Zepbound single-dose vial is "Despite obesity being recognized as a serious chronic illness with long-term consequences, it's often misclassified as a lifestyle choice, resulting in many employers and the federal government excluding medications like Zepbound from insurance coverage," said Jonsson

CPT1A is known to be expressed in the liver, lymphocytes, and fibroblasts [18], but its expression and location in FLS are unknown

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Of note, this trial employed an individualized titration schedule on a variety of background regimens, which is likely more applicable to typical clinical practice