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When To See a Doctor As with most symptoms or side effects of GLP-1s, severity is the main concern

Patients should also make necessary lifestyle changes, such as regular exercise and a reduced-calorie diet

Beginning at the lowest effective dose helps in minimizing potential side effects while allowing for gradual acclimatization

Many commercial plans now cover GLP-1s for weight loss with a prior authorization that requires documented BMI criteria and evidence of a prior weight loss attempt

In the S-LITE trial, people who added an exercise program while holding a big weight loss preserved their lean mass and improved their fitness, while the group on the drug alone did not (Lundgren et al., 2021)