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In cases where another chronic condition is causing B12 deficiency, patients may be recommended to come in every 2 or 3 months for injections to keep symptoms under control

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Colchicine, Neomycin, Aminosalicylic Acid, H2-blockers (e.g., Ranitidine), and Proton Pump Inhibitors (PPIs, e.g., Omeprazole): These oral medications can all interfere with the intestinal absorption of dietary B12, making the need for injectable B12 more pronounced