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This anomaly may arise from confounding factors such as metformin exposure or consumption of polyphenol-rich green tea, though mechanistic validation is pending ( Butyrivibrio , Bifidobacterium bifidum , Megasphaera , Prevotella , Escherichia coli ), which may obscure true microbiota-disease relationships ( 3 Impacts of gut microbiota dysbiosis on gastrointestinal nerves and function In the diabetic state, gut microbiota dysbiosis further exacerbates GI motility dysfunction and impairs the ENS

This led Pfizer to focus on the development of a once-daily version of the drug, which showed early success in Phase I trials (NCT06567327 and NCT06568731)

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Cardiovascular effects of glucagon-like peptide 1 receptor agonists: from mechanistic studies in humans to clinical outcomes