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PT-141 interacts with melanocortin receptors within the brain, making it suitable for studying CNS-driven mechanisms independent of peripheral blood-flow variables

Although initially implicated in muscle fat degeneration, heterotopic ossification, and fibrosis, FAPs are now recognized as essential for skeletal muscle homeostasisc (190)

Kraft, M., Kraft, K., Gartner, S., Mayerle, J., Simon, P., Weber, E., Schutte, K., Stieler, J., Koula-Jenik, H., Holzhauer, P., Grober, U., Engel, G., Muller, C., Feng, Y

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This activation enhances natural GH pulses without directly supplying exogenous hormone