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Macrophage ferroptosis was first described in hemochromatosis, where iron citrate overload can induce ferroptosis in primary mouse hepatocytes and bone marrow-derived macrophages, accompanied by upregulation of Solute Carrier Family 7 member 11(SLC7A11), increased ROS, and increased nuclear Nrf2 [59]

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Insurance coverage exists for qualifying indications, though coverage varies by plan and diagnosis

doi: 10.1007/s40261-016-0389-8 85 CaoCYangSZhouZ

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