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Cukierman-Yaffe T, Gerstein HC, Colhoun HM et al

Sci Rep 7:979 Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV (2015) Impaired vascular-mediated clearance of brain amyloid beta in Alzheimers disease: the role, regulation and restoration of LRP1

1 Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently one of the most important public health issues in the world because it is directly related to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) (1, 2)

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The potential for hepatotoxicity develops when large doses of acetaminophen saturate the typical conjugation pathways and overwhelm available glutathione stores, leading to reduced clearance of the toxic metabolite