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GLP-1 receptor agonists (GLP-1RAs), primarily developed for their metabolic effects 6,7,8 , demonstrated neuroprotective activity in preclinical models over two decades ago 9 with subsequent studies revealing anti-inflammatory effects in both central and peripheral tissues 10

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Although this data analysis was performed in late 2024, there are some well-proven clinical benefits of GLP-1 medications which the researchers did not include in this model

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At the time of the initial examination, optical coherence tomography (OCT) scans were performed using the DRI-OCT Triton (TopCon Healthcare, Tokyo, Japan)