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Chronic activation of NF-B by oxidative stress can lead to sustained inflammation and the perpetuation of autoimmune responses [135]

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In many cases, these effects diminish or disappear entirely with subsequent administrations as the biological system acclimates

Mar 2022;180:131-146

Thus, the different volume regulation by SGLT2-I may limit the aberrant neurohumoral and RAAS stimulation that occurs in the setting of volume depletion (54, 55)