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Accordingly, several in vitro studies aimed at assessing the efficacy of drugs on glucose-related cell damage in ARPE-19 reported that using euglycemic media (5.5 mM) as a control condition may affect normal cell growth [48]

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the evidence elevated the expression of miRNA modification among disease state and healthy, indicating the methylation of disease-specific patterns (Van den Hove et al., 2014)

Based on this observation, it is proposed that severe hyperhomocysteinemia plays a role in the etiology of cardiovascular disease