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doi: 10.1111/micc.12186 210 Carranza-NavalMJDel MarcoAHierro-BujalanceCAlves-MartinezPInfante-GarciaCVargas-SoriaMet al

Without intrinsic factor, the small intestine cannot efficiently absorb dietary B12 through the normal receptor-mediated pathway

Normal intramuscular dose of vitamin B12

DNA vaccines encoding HSP90 reduce lupus manifestations and prolong survival in lupus-prone mice by inducing tolerogenic dendritic cells and expanding regulatory T cells (Tregs), thereby suppressing autoimmune responses

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29 Collectively, these insights reinforce that autophagy is neither merely a degradation pathway nor a binary process but a carefully tuned homeostatic program that determines whether the myocardium adapts or deteriorates under stress