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If the researcher is in a significant caloric deficit, fasting, or following a very low carbohydrate diet, the baseline glucose substrate available is lower, and the combined glucose-lowering effects of both compounds can push levels into symptomatic ranges

Stay hydrated Drinking plenty of water helps digestion and can reduce bloating and stomach pain

Peppermint tea or ginger may soothe digestive discomfort naturally

Patients with pre-existing conditions should be particularly vigilant

NICE-appraised licensed alternatives such as semaglutide (Wegovy) and liraglutide (Saxenda) are available through regulated UK weight management services

This includes discussing lifestyle modifications, monitoring blood pressure, and addressing any concerns or misconceptions that patients may have